Hansreudi Schmacher and Matthias Rickenbach have both been indicted on suspicion of fraud as the country continues its efforts to clamp down on the number of US citizens evading tax payments by using Swiss bank accounts.
Internal Revenue Service commissioner Doug Shulman described the move as "another step in our ongoing effort to pursue hidden offshore assets - no matter where they are located".
The pair allegedly helped their clients in the US move their money back into the country undetected, along with creating false documents to conceal assets, according to the AFP.
This is the latest step the US has taken in an investigation that has largely focused on UBS.
Earlier this month, the two parties agreed a deal that has resulted in the Swiss bank handing over account details of thousands of US citizens who hold offshore accounts in the country.
Written by Tony Aynsley